Blue jar of ZO Skin Health Growth Factor Serum on a white background

Blue skincare jar with text on skin improvement results after 2, 8, and 12 weeks.

Woman touching her face with text on skin improvement benefits on a gray background ZO Growth FActor Serum New

Close-up of the new zo skin health growth factor serum with text about human-comparable growth factor technology on a white background.

Blue jar of ZO Skin Health Growth Factor Serum on a gray background

ZO Skin Health

ZO Growth Factor Serum

Name: ZO Growth Factor Serum
Brand: ZO Skin Health
SKU: ZOAA0004
Rating: 4.9 (45 reviews)

£124 30ml | 1 Fl. Oz.

Key Benefits

Clinically proven to improve overall appearance of skin.
Reduces appearance of fine lines and wrinkles.
Improves skin firmness and elasticity.
Restores hydration and reinforces the skin's natural protective barrier.

Targets

Ageing skin
Dry skin
Sensitive skin

When to use

Morning
Evening

Product details

The reformulated ZO Skin Health Growth Factor Serum is an advanced anti-ageing serum clinically proven to support visibly younger-looking skin. Powered by innovative, bioengineered growth factor technology designed to mimic natural skin signalling, this next-generation formula helps improve the appearance of skin density, firmness, elasticity and smoothness.

With continued use, skin appears stronger, smoother and more supple, while fine lines and visible signs of skin ageing are visibly reduced. In clinical evaluation after 8 weeks of use, participants reported skin that looked nearly 6 years younger.*

Lightweight and suitable for all skin types, Growth Factor Serum is designed to support long-term skin rejuvenation and overall skin health.

Directions for use

Cleanse your face with a mild cleanser and pat your skin dry.
Squeeze a small amount of the serum onto your fingertips.
Gently massage the serum into your skin, using upward and outward strokes to help it absorb.
Allow the serum to work for a few minutes, then follow up with the rest of your skincare routine.

Key ingredients

Human-comparable Growth Factor Technology: Works to reverse the visible signs of ageing and aid in the appearance of skin rejuvenation and vitality.
ZPRO® - Supports skin’s natural replenishment of hyaluronic acid.
Plant- + Enzymatically-Derived Growth Factors: Restores the appearance of skin density, compactness, and visible strength.
Dipeptide diaminobutyroyl benzylamide diacetate: Minimizes the appearance of expression lines

All ingredients

qua/Water/Eau, Dimethicone, Butylene Glycol, Glycerin, Caprylyl Methicone, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone/PPG-20 Crosspolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, 1,2-Hexanediol, Caprylyl Glycol, Sodium Hyaluronate, Sodium Chloride, Dimethicone Crosspolymer, Lactobacillus Ferment, Scutellaria Baicalensis Root Extract, Sodium Citrate, Hydrolyzed Sericin, Phospholipids, Acetyl Glutamine, Lecithin, Buddleja Davidii Meristem Cell Culture, Cordyceps Militaris Mycelium Extract, Glycyrrhiza Uralensis (Licorice) Root Extract, Dipropylene Glycol, Pentylene Glycol, Xanthan Gum, Beta-Glucan, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Ferment Filtrate, Hexylene Glycol, Phenoxyethanol, Potassium Sorbate, Tocopherol, Disodium Acetyl Glucosamine Phosphate, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Bacillus/Folic Acid Ferment Filtrate Extract, Hexamethylindanopyran, Terpineol, Tetramethyl Acetyloctahydronaphthalenes, Fragrance/Parfum. ZO are continually innovating and adapting to new regulations. As a result, depending on when and where the product was purchased, the ingredient lists on this website may differ from product packaging. Please refer to your product packaging for ingredient information specific to your product.

Watch the video

Experts explain

Watch ZO's video to learn more about the reformulated ZO Growth Factor Serum

Reviews

ZO Growth Factor Serum FAQs

What is the ZO Skin Health Growth Factor Serum?

ZO Skin Health Growth Factor Serum is an advanced anti-ageing serum clinically shown to restore a younger-looking complexion. The reformulated 2026 formula is powered by safely synthesised, human-comparable growth factors that deliver targeted cellular signalling to visibly improve skin density, elasticity, firmness, and smoothness.

What has changed in the new ZO Growth Factor Serum formula?

The reformulated Growth Factor Serum features a next-generation blend of human-comparable growth factors (Sh-Oligopeptides and Sh-Polypeptides) alongside plant- and enzymatically-derived growth factors, ZPRO® technology, and a neuropeptide (Dipeptide Diaminobutyroyl Benzylamide Diacetate) to minimise the appearance of expression lines. The updated formula delivers measurably stronger clinical results than its predecessor.

What results can I expect from the ZO Growth Factor Serum?

In an independent 12-week clinical study of 46 subjects: 100% agreed their skin looked lifted and supported 98% agreed their skin looked rejuvenated 42% improvement in visible radiance and texture 26% improvement in hydration 16% improvement in elasticity 15% improvement in the appearance of fine lines After just 8 weeks, users reported skin that appeared nearly 6 years younger.

Who is the ZO Growth Factor Serum suitable for?

The serum is formulated for all skin types and is particularly beneficial for anyone with moderate to visible signs of ageing, including loss of firmness, fine lines, dullness, and reduced skin density. It is non-comedogenic, paraben-free, and formulated without gluten, making it suitable for most sensitive skin types too.

How do I use the ZO Skin Health Growth Factor Serum?

After completing your Getting Skin Ready® steps, apply the serum to clean, dry skin morning and evening. It sits within your Prevent + Correct routine, before heavier creams or moisturisers. Always follow with a broad-spectrum SPF 50 sunscreen during the day.

Can I use the ZO Growth Factor Serum with retinol?

Yes. Growth factors and retinol complement each other well. Apply the Growth Factor Serum first to slightly damp skin, allow it to absorb, then follow with your retinol product as part of your PM routine. The serum supports skin's natural regeneration and can help offset some of the dryness or sensitivity that retinol may cause.

What products pair well with the ZO Growth Factor Serum?

ZO recommends pairing the Growth Factor Serum with ZO Daily Power Defense (for antioxidant protection and DNA repair support) and the Growth Factor Eye Serum (for targeting the delicate eye area). For a complete protocol, use alongside ZO Gentle Cleanser and a broad-spectrum SPF 50 sunscreen.

Is the ZO Growth Factor Serum worth the investment?

The Growth Factor Serum has been independently, third-party clinically tested — not just lab-assessed — with results across 46 subjects measured by expert graders and medical-grade instruments. For those seeking a premium, evidence-backed anti-ageing serum that addresses skin density, firmness, and expression lines simultaneously, it represents one of the most scientifically substantiated serums in the ZO range.

Where can I buy the ZO Skin Health Growth Factor Serum in the UK?

You can purchase the ZO Skin Health Growth Factor Serum through authorised ZO partners, including Face Dr. Buying through an authorised clinic ensures you receive the genuine, reformulated product — and access to expert skincare guidance on the right ZO protocol for your skin.

Care that's more than skin deep